Description

(S)-2-Benzyl-2-n-Bocamino-Ethyl Thiol is a high-purity chiral building block featuring a protected amino group and a thiol functionality. This compound is critical for the synthesis of complex molecules where stereochemical integrity and selective reactivity are paramount. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and biotechnology industries for applications in peptide mimetics, drug discovery, and the development of active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, particularly in peptide-based drug discovery.
• Peptide Mimetics Synthesis: Used to introduce non-natural amino acid residues with a thiol side chain, enabling the creation of stabilized peptide structures and constrained analogs.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands in asymmetric catalysis or for constructing functionalized surfaces in material science.
• Bioconjugation Chemistry: The thiol group allows for site-specific conjugation to maleimides or other electrophiles, useful in creating antibody-drug conjugates (ADCs) or protein labeling.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes or inhibitors that target cysteine proteases or other thiol-reactive enzymes.
• Academic and Industrial R&D: A valuable reagent for methodological studies in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	(S)-2-Benzyl-2-n-Bocamino-Ethyl Thiol
CAS No.	141437-85-6
Molecular Formula	C₁₅H₂₃NO₂S
Molecular Weight	281.41 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-3-phenylpropanethiol; (S)-2-(Boc-amino)-3-phenyl-1-propanethiol; Boc-Cys(Bzl)-OH thiol derivative; tert-Butyl (1-mercapto-3-phenylpropan-2-yl)carbamate; (S)-2-Benzyl-2-((tert-butoxycarbonyl)amino)ethanethiol; N-Boc-S-benzyl-L-cysteinol; N-(tert-Butoxycarbonyl)-S-benzyl-L-cysteinethiol
EINECS	Contact for details

Quality Control

Our (S)-2-Benzyl-2-n-Bocamino-Ethyl Thiol is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized by comprehensive analytical techniques including HPLC, NMR, and optical rotation measurement. A Certificate of Analysis (COA) detailing purity, chiral purity, and identity is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to minimize oxidation and degradation of the thiol group. Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.