Description

2,2,2-Trifluoro-1-Triphenylsilanyl-Ethanone is a specialized organosilicon reagent featuring a trifluoroacetyl group protected by a triphenylsilyl moiety. This compound is a valuable building block in advanced organic synthesis, particularly for the controlled introduction of the trifluoroacetyl group under mild conditions. It is primarily utilized by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel fluorinated compounds. The unique silyl-protected ketone structure offers enhanced stability and selectivity in key synthetic transformations.

Application

• Pharmaceutical Intermediate: A key reagent for the synthesis of fluorinated active pharmaceutical ingredients (APIs) and drug candidates, leveraging the metabolic stability imparted by the trifluoromethyl group.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where fluorine atoms enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialty polymers, coatings, and fluorinated materials with unique surface properties.
• Organic Synthesis Reagent: Acts as a stable trifluoroacetyl anion equivalent in nucleophilic addition reactions, Grignard reactions, and other carbon-carbon bond-forming processes.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands and organometallic catalysts for asymmetric synthesis and catalysis research.
• Fluorine-19 NMR Spectroscopy: Can be used as a reference standard or a synthetic handle for introducing 19F NMR tags into complex molecules for analytical purposes.

Basic Information

Product Name	2,2,2-Trifluoro-1-Triphenylsilanyl-Ethanone
CAS No.	141334-25-0
Molecular Formula	C20H15F3OSi
Molecular Weight	356.41 g/mol
Synonyms	1-(Triphenylsilyl)-2,2,2-trifluoroethanone; 2,2,2-Trifluoro-1-(triphenylsilyl)ethanone; Trifluoro(triphenylsilyl)methanone; Triphenyl(trifluoroacetyl)silane; α,α,α-Trifluoroacetophenone triphenylsilyl enol ether; (Trifluoroacetyl)triphenylsilane; TPS-trifluoroacetone; Triphenylsilyl trifluoroacetate ketone equivalent
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-Triphenylsilanyl-Ethanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and industrial synthesis. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR spectroscopy. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP guidelines where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.