Description

Acyclovir-Side Chain-2-3H is a key deuterated intermediate in the synthesis of the antiviral drug Acyclovir. This compound is critical for pharmaceutical research and development, particularly in the creation of isotopically labeled analogs for metabolic and pharmacokinetic studies. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and academic institutions engaged in advanced antiviral drug development and analytical method validation.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of deuterium-labeled Acyclovir and its prodrugs.
• Metabolic Tracing: Used as a stable isotope-labeled tracer in drug metabolism and pharmacokinetics (DMPK) studies to track the fate of the drug molecule in biological systems.
• Internal Standard for Analytics: Serves as a high-purity reference standard in LC-MS and GC-MS methods for the quantitative analysis of Acyclovir in biological matrices.
• Isotope Effect Research: Enables investigation of deuterium isotope effects on the potency, selectivity, and metabolic stability of antiviral nucleoside analogs.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable synthesis of labeled active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Acyclovir-Side Chain-2-3H
CAS No.	141294-79-3
Molecular Formula	C8H10D3N5O3
Molecular Weight	228.25 g/mol
Synonyms	2-[(2-Amino-1,6-dihydro-6-oxo-9H-purin-9-yl)methoxy]ethyl Acetate-2,2,2-d3; 9-[(2-Acetoxyethoxy)methyl]guanine-2',2',2'-d3; Acyclovir Side Chain-d3; Deuterated Acyclovir Intermediate; 2',2',2'-Trideutero-2',2',2'-trideutero-9-[(2-acetoxyethoxy)methyl]guanine; Acyclovir Impurity D-d3 (related); NSC 760493-d3
EINECS	Contact for details

Quality Control

Our Acyclovir-Side Chain-2-3H is manufactured under controlled conditions to ensure high chemical and isotopic purity, suitable for sensitive analytical and research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as chemical purity (by HPLC), isotopic enrichment (by MS), and identification. We adhere to strict internal quality standards aligned with ICH guidelines for impurities. COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing at 2-8°C to ensure optimal stability of the deuterated label.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.