Description

(-)-Ipratropine is a specific enantiomer of ipratropine, a compound of significant interest in advanced pharmaceutical research and development. This high-purity chiral building block is essential for synthesizing enantiomerically pure active pharmaceutical ingredients (APIs) and reference standards. It is primarily utilized by pharmaceutical companies and contract research organizations (CROs) focused on developing novel anticholinergic agents, respiratory therapeutics, and for conducting detailed pharmacological studies.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of enantiomerically pure anticholinergic drugs.
• Active Pharmaceutical Ingredient (API) Development: Used in R&D for creating new respiratory medications targeting conditions like chronic obstructive pulmonary disease (COPD) and asthma.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Pharmacological Research: Employed in preclinical studies to investigate the specific biological activity and receptor binding profiles of the (-)-enantiomer.
• Process Chemistry: Used in route scouting and optimization for the commercial-scale manufacturing of ipratropium-based APIs.

Basic Information

Product Name	(-)-Ipratropine
CAS No.	141197-27-5
Molecular Formula	C20H30NO3
Molecular Weight	332.46 g/mol
Synonyms	(-)-Ipratropium Related Compound A; (8r)-3-(3-Hydroxy-1-oxo-2-phenylpropoxy)-8-methyl-8-(1-methylethyl)-8-azoniabicyclo[3.2.1]octane; (1R,5S)-3-(3-Hydroxy-2-phenylpropanoyloxy)-8-methyl-8-isopropyl-8-azoniabicyclo[3.2.1]octane; Ipratropine Enantiomer; L-Ipratropine; Ipratropium Impurity A
EINECS	Contact for details

Quality Control

Our (-)-Ipratropine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay and impurity profiling, to ensure it meets the stringent requirements for pharmaceutical R&D and intermediate use. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant use and inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.