Description

(+)-Ipratropine CAS NO 141197-26-4 is a high-purity, single-enantiomer form of the anticholinergic agent ipratropium. This optically active compound is of significant interest for advanced pharmaceutical research and development, particularly in the study of stereoselective drug action and receptor binding. It serves as a critical chiral intermediate or reference standard for analytical and synthetic applications within the life sciences sector. Organizations engaged in the development of respiratory therapeutics, neuropharmacological agents, and chiral separation methods are the primary industrial users of this specialized material.

Application

• Pharmaceutical Reference Standard: Used as a certified standard for quality control and analytical method development in drug manufacturing.
• Chiral Intermediate: Serves as a key building block in the enantioselective synthesis of novel therapeutic agents targeting muscarinic receptors.
• Biochemical Research: Employed in in vitro studies to investigate the pharmacological profile and metabolic pathways of the (+)-enantiomer.
• Analytical Method Development: Essential for developing and validating chiral HPLC or SFC methods to separate and quantify ipratropium enantiomers.
• Formulation Research: Used in pre-formulation studies for inhalable or other dosage forms requiring high stereochemical purity.

Basic Information

Product Name	(+)-Ipratropine
CAS No.	141197-26-4
Molecular Formula	C20H30BrNO3
Molecular Weight	412.36 g/mol
Synonyms	(+)-Ipratropium; (8r)-3α-Hydroxy-8-isopropyl-1αh,5αh-tropanium bromide (±)-tropate; (1R,3r,5S,8r)-3-[(2S)-3-Hydroxy-2-phenylpropanoyl]oxy-8-isopropyl-8-methyl-8-azoniabicyclo[3.2.1]octane bromide; Dexipratropium; Ipratropium bromide enantiomer (+); (8R)-Ipratropium bromide
EINECS	Contact for details

Quality Control

Our (+)-Ipratropine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assay, identification, and control of specified impurities, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The material is hygroscopic (moisture-sensitive); ensure the container is sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.