Description

(+)-(S)-Methyl α-[[2-(2-Thienyl)Ethyl]Amino]-α-(2-Chlorophenyl)Acetate is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its core value lies in its stereospecific structure, which is critical for the development of enantiomerically pure active pharmaceutical ingredients (APIs) with targeted therapeutic effects. This compound is primarily needed by research institutions and manufacturers in the pharmaceutical industry engaged in the development of novel drugs, particularly in areas requiring sophisticated chiral building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a building block in stereoselective synthesis to construct complex molecules with defined three-dimensional architecture.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved efficacy and safety profiles.
• Process Chemistry Development: Used in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Reference Standard: Acts as a high-purity analytical standard for method development and quality control in pharmaceutical analysis.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Item	Detail
Product Name	(+)-(S)-Methyl α-[[2-(2-Thienyl)Ethyl]Amino]-α-(2-Chlorophenyl)Acetate
CAS No.	141109-20-8
Molecular Formula	C16H18ClNO2S
Molecular Weight	323.84 g/mol
Synonyms	(S)-Methyl 2-((2-(Thiophen-2-yl)ethyl)amino)-2-(2-chlorophenyl)acetate; Methyl (S)-α-[[2-(2-Thienyl)ethyl]amino]-α-(2-chlorophenyl)acetate; (S)-2-((2-(Thiophen-2-yl)ethyl)amino)-2-(2-chlorophenyl)acetic acid methyl ester; (S)-Methyl 2-amino-2-(2-chlorophenyl)-3-(thiophen-2-yl)propanoate (tautomeric form); UNII-9I4JYH6V6R; SCHEMBL218422; (+)-S-Methyl α-((2-(2-Thienyl)ethyl)amino)-α-(2-chlorophenyl)acetate
EINECS	Contact for details

Quality Control

Our (+)-(S)-Methyl α-[[2-(2-Thienyl)Ethyl]Amino]-α-(2-Chlorophenyl)Acetate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and available upon request to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.