Description

(+)Methyl α-(2-Thienylethylamino)(2-Chlorophenyl)Acetate Hcl is a high-purity chiral intermediate of significant importance in advanced pharmaceutical synthesis. Its value lies in its specific stereochemistry and functional groups, which make it a critical building block for the development of novel active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of targeted therapeutics, particularly within central nervous system (CNS) and other specialized drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new chemical entities (NCEs).
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Asymmetric Synthesis: Employed in reactions requiring high enantiomeric purity due to its defined stereocenter.
• Medicinal Chemistry Research: A valuable tool for structure-activity relationship (SAR) studies in drug discovery pipelines.
• Reference Standard: Can be utilized as an analytical standard for quality control and method development in pharmaceutical analysis.
• Process Chemistry Development: Used for scaling up synthetic routes from laboratory to pilot plant scale.

Basic Information

Product Name	(+)Methyl α-(2-Thienylethylamino)(2-Chlorophenyl)Acetate Hydrochloride
CAS No.	141109-18-4
Molecular Formula	C15H18ClNO2S • HCl
Molecular Weight	364.69 g/mol
Synonyms	(+)-Methyl α-[(2-Thienyl)ethylamino]-(2-chlorophenyl)acetate hydrochloride; (R)-Methyl 2-((1-(thiophen-2-yl)propan-2-yl)amino)-2-(2-chlorophenyl)acetate hydrochloride; Methyl (R)-2-((1-(thiophen-2-yl)propan-2-yl)amino)-2-(2-chlorophenyl)acetate HCl; (R)-2-((1-(Thiophen-2-yl)propan-2-yl)amino)-2-(2-chlorophenyl)acetic acid methyl ester hydrochloride; CAS 141109-18-4; Thienylethylamino chlorophenyl acetate ester HCl salt
EINECS	Contact for details

Quality Control

Our (+)Methyl α-(2-Thienylethylamino)(2-Chlorophenyl)Acetate Hcl is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.