Description

1-(5-Isoquinolinylsulfonyl)-3-Methyl-Piperazine Dihydrochloride is a high-purity, specialized organic compound primarily used as a key intermediate in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of biologically active molecules, particularly those targeting specific enzymatic pathways. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require reliable, high-quality building blocks for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel therapeutic agents, particularly kinase inhibitors and other targeted small molecules.
• Biochemical Research: Used as a tool compound or precursor in enzymatic studies and proteomics research to investigate cellular signaling pathways.
• Organic Synthesis: Serves as a versatile sulfonamide-containing scaffold for constructing complex heterocyclic compounds in medicinal chemistry.
• API Development: Employed in the research and process development stages for new Active Pharmaceutical Ingredients (APIs).
• Reference Standard: Can be utilized as a high-purity analytical standard for quality control and method validation in laboratory settings.

Basic Information

Product Name	1-(5-Isoquinolinylsulfonyl)-3-Methyl-Piperazine Dihydrochloride
CAS No.	140663-38-3
Molecular Formula	C14H18N4O2S • 2HCl
Molecular Weight	407.32 g/mol
Synonyms	3-Methyl-1-(5-isoquinolinylsulfonyl)piperazine dihydrochloride; 1-(Isoquinolin-5-ylsulfonyl)-3-methylpiperazine dihydrochloride; 3-Methyl-1-(isoquinoline-5-sulfonyl)piperazine dihydrochloride; H-1152 dihydrochloride; HA-1152 dihydrochloride; Rho-kinase inhibitor H-1152; (3-Methyl-1-(quinolin-5-ylsulfonyl)piperazine dihydrochloride)
EINECS	Contact for details

Quality Control

Our 1-(5-Isoquinolinylsulfonyl)-3-Methyl-Piperazine Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for research and development use. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.