Description

1-((4-Trifluoromethylphenyl)Methyl)-1H-Pyrrole-2,5-Dione is a specialized heterocyclic compound featuring a pyrrole-2,5-dione (maleimide) core substituted with a trifluoromethylbenzyl group. This structure makes it a valuable high-purity chemical intermediate for advanced synthesis, particularly in the development of pharmaceuticals and agrochemicals where the trifluoromethyl moiety is prized for its ability to modulate lipophilicity and metabolic stability. It is primarily sought by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing complex active molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the CF3 group enhances biological activity and environmental persistence.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the development of specialized polymers, coatings, and adhesives with unique thermal or chemical resistance.
• Bioconjugation Reagent: The maleimide group is reactive towards thiols, making this compound useful for creating protein conjugates, antibody-drug conjugates (ADCs), and diagnostic probes in biotech research.
• Organic Electronic Materials: Investigated as a component in the synthesis of organic semiconductors or charge-transport materials for electronic devices.

Basic Information

Product Name	1-((4-Trifluoromethylphenyl)Methyl)-1H-Pyrrole-2,5-Dione
CAS No.	140481-02-3
Molecular Formula	C12H8F3NO2
Molecular Weight	255.19 g/mol
Synonyms	N-[(4-Trifluoromethyl)benzyl]maleimide; 1-[(4-Trifluoromethylphenyl)methyl]-1H-pyrrole-2,5-dione; N-(4-Trifluoromethylbenzyl)maleimide; 1-[(4-Trifluoromethylbenzyl)]-1H-pyrrole-2,5-dione; N-(alpha,alpha,α-Trifluoro-p-tolyl)maleimide; (4-Trifluoromethylbenzyl)maleimide; Maleimide, N-[(4-trifluoromethyl)benzyl]-
EINECS	Contact for details

Quality Control

Our production of 1-((4-Trifluoromethylphenyl)Methyl)-1H-Pyrrole-2,5-Dione adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis by GC. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP-grade specifications for advanced synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.