Description

Formamide, n-[2-Hydroxy-5-[1-Hydroxy-2-[[2-(4-Methoxyphenyl)-1-Methylethyl]Amino]Ethyl]Phenyl]-, [R-(R*,S*)]-, (E)-2-Butenedioate (2:1) (Salt) is a high-purity, non-racemic salt form of a complex formamide derivative, designed for advanced pharmaceutical synthesis and research. This compound is valued for its role as a key chiral intermediate in the development of active pharmaceutical ingredients (APIs), particularly those targeting adrenergic receptors. It is essential for pharmaceutical manufacturers and contract research organizations (CROs) engaged in the synthesis of sophisticated therapeutic agents, where precise stereochemistry and consistent quality are paramount.

Application

• Pharmaceutical Intermediate: A critical chiral building block in the multi-step synthesis of complex drug molecules, particularly β-adrenergic blocking agents.
• Active Pharmaceutical Ingredient (API) Development: Used in research and process development for novel APIs where the specific stereochemistry of the salt is required for biological activity.
• Asymmetric Synthesis: Serves as a precursor in catalytic and stoichiometric asymmetric synthesis routes due to its defined [R-(R*,S*)] configuration.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and validation of related pharmaceutical compounds.
• Process Chemistry Research: Utilized in academic and industrial R&D for exploring new synthetic methodologies and optimizing existing manufacturing processes.

Basic Information

Product Name	Formamide, n-[2-Hydroxy-5-[1-Hydroxy-2-[[2-(4-Methoxyphenyl)-1-Methylethyl]Amino]Ethyl]Phenyl]-, [R-(R*,S*)]-, (E)-2-Butenedioate (2:1) (Salt)
CAS No.	140173-34-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(R,R)-Formoterol Fumarate; (R,R)-Formoterol Fumarate Salt; Arformoterol Impurity; (R,R)-Formoterol (E)-2-Butenedioate; 140173-34-8; (R,R)-Formoterol Fumaric Acid Salt; (R,R)-Formamide Derivative Fumarate; N-[2-Hydroxy-5-[(1R)-1-Hydroxy-2-[[(1R)-2-(4-Methoxyphenyl)-1-Methylethyl]Amino]Ethyl]Phenyl]formamide (E)-2-Butenedioate (2:1)
EINECS	Contact for details

Quality Control

Our Formamide derivative salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, assay, chiral purity, and related substances are provided and can be tailored to meet specific client or regulatory requirements (e.g., ICH guidelines).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to protect from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% (R,R isomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.