Description

2-Chloro-5-Ethynyl-Thiophene is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its unique molecular architecture, combining a reactive ethynyl group with a halogenated thiophene core, enabling precise cross-coupling and cycloaddition reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in constructing advanced active ingredients for crop protection products.
• Organic Electronic Materials: Serves as a precursor for conjugated polymers and small molecules in OLEDs, OFETs, and organic photovoltaics.
• Ligand and Catalyst Development: Functionalized to create specialized ligands for transition metal catalysis.
• Chemical Biology Probes: Employed in click chemistry applications for bioconjugation and labeling studies.
• Academic & Industrial R&D: A versatile building block for exploratory chemistry and process optimization in fine chemical production.

Basic Information

Product Name	2-Chloro-5-Ethynyl-Thiophene
CAS No.	139957-82-7
Molecular Formula	C6H3ClS
Molecular Weight	142.60 g/mol
Synonyms	5-Ethynyl-2-chlorothiophene; 2-Chloro-5-ethynylthiophene; Thiophene, 2-chloro-5-ethynyl-; 2-Chloro-5-thienylethyne; 139957-82-7
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Ethynyl-Thiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our commitment to quality supports applications requiring high-purity intermediates for GMP and non-GMP synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The product is compatible with strong acids and organic solvents but should be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.