Description

2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, ethyl ester (9CI) is a specialized bicyclic organic compound featuring a bridged nitrogen-containing structure, making it a valuable chiral building block and synthetic intermediate. Its rigid, constrained framework is crucial for constructing complex molecules with precise stereochemistry, which is essential in advanced pharmaceutical and agrochemical research. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, fine chemical, and material science industries for applications in asymmetric synthesis and medicinal chemistry.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of neurologically active compounds and enzyme inhibitors.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of novel chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Agrochemical Research: Used in the development of novel, stereochemically defined pesticides and herbicides where specific biological activity is required.
• Fine Chemical Synthesis: Employed in the multi-step synthesis of complex natural products and other high-value specialty chemicals.
• Material Science: Investigated as a monomer or precursor for creating polymers with unique thermal or mechanical properties due to its strained bicyclic structure.

Basic Information

Product Name	2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, ethyl ester (9CI)
CAS No.	139927-19-8
Molecular Formula	C9H13NO2
Molecular Weight	167.21 g/mol
Synonyms	Ethyl 2-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid ethyl ester; 1-Aza-4-ethyl bicyclo[2.2.1]hept-5-ene-3-carboxylate; 139927-19-8; Ethyl 1-azabicyclo[2.2.1]hept-5-ene-3-carboxylate; Bicyclic β-amino acid ester derivative
EINECS	Contact for details

Quality Control

Our 2-Azabicyclo[2.2.1]hept-5-ene-3-carboxylic acid, ethyl ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP compliance for advanced intermediate production, ensuring reliability for critical synthetic pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. Store away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Purity (GC)	≥ 96.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.