Description

(((1R,3R)-5-(2-Chloroethylidene)Cyclohexane-1,3-Diyl)Bis(Oxy)) Bis(tert-Butyldimethylsilane) is a high-purity, advanced pharmaceutical intermediate featuring a protected diol functionality. This compound is critical for enabling complex synthetic routes in medicinal chemistry, particularly where selective deprotection and subsequent functionalization are required. It is primarily utilized by research institutions and pharmaceutical manufacturers for the development of novel active pharmaceutical ingredients (APIs) and other fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in discovery and process development for creating new chemical entities with potential therapeutic value.
• Silyl Protection Reagent: Serves as a protecting group for diols in complex organic syntheses, allowing for selective reactions at other sites on the molecule.
• Fine Chemical Synthesis: Employed in the production of specialty chemicals, catalysts, and ligands for asymmetric synthesis.
• Academic & Industrial R&D: A valuable reagent for methodological studies and scaling up novel synthetic pathways in laboratory and pilot plant settings.

Basic Information

Product Name	(((1R,3R)-5-(2-Chloroethylidene)Cyclohexane-1,3-Diyl)Bis(Oxy)) Bis(tert-Butyldimethylsilane)
CAS No.	139356-38-0
Molecular Formula	C20H41ClO2Si2
Molecular Weight	413.2 g/mol
Synonyms	1,3-Bis-O-(tert-butyldimethylsilyl)-5-(2-chloroethylidene)cyclohexane-1,3-diol; (1R,3R)-5-(2-Chloroethylidene)-1,3-cyclohexanediol bis(tert-butyldimethylsilyl) ether; TBDMS-protected chloroethylidene cyclohexanediol; tert-Butyldimethyl((1R,3R)-5-(2-chloroethylidene)-1,3-cyclohexanediyl) bis(oxy)bis(dimethylsilane); (1R,3R)-5-(2-Chloroethylidene)cyclohexane-1,3-diyl bis(tert-butyldimethylsilyl) ether
EINECS	Contact for details

Quality Control

Our (((1R,3R)-5-(2-Chloroethylidene)Cyclohexane-1,3-Diyl)Bis(Oxy)) Bis(tert-Butyldimethylsilane) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and chiral purity analysis, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong acids and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.