Description

Tolafentrine is a selective phosphodiesterase 4 (PDE4) inhibitor with significant bronchodilatory and anti-inflammatory properties. This compound is of primary interest in pharmaceutical research and development for its potential in treating respiratory disorders such as asthma and chronic obstructive pulmonary disease (COPD). It serves as a critical intermediate and reference standard for researchers, process chemists, and manufacturers in the global life sciences sector.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting PDE4.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: A vital tool for studying PDE4 enzyme kinetics, inhibition mechanisms, and signal transduction pathways in preclinical models.
• Respiratory Drug Development: Investigated for its therapeutic potential in developing novel treatments for inflammatory airway diseases.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of related drug candidates.

Basic Information

Product Name	Tolafentrine
CAS No.	139308-65-9
Molecular Formula	C20H21N3O2
Molecular Weight	335.40 g/mol
Synonyms	4-(3-Cyclopentyloxy-4-methoxyphenyl)-2-pyrrolidinone; BY 217; PDE4 Inhibitor BY217; 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-; Tolafentrine hydrochloride (salt form)
EINECS	Contact for details

Quality Control

Our Tolafentrine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.