Description

Calciumvalproat-Dihydrat CAS NO 138995-18-3 is the calcium salt of valproic acid, a well-established active pharmaceutical ingredient (API) and key intermediate. This compound is valued for its stability and bioavailability in the formulation of critical neurological and psychiatric medications. It is primarily required by pharmaceutical manufacturers and advanced research institutions developing treatments for epilepsy, bipolar disorder, and migraine prophylaxis.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of antiepileptic and mood-stabilizing drugs.
• Key Chemical Intermediate for the synthesis of advanced valproate derivatives and prodrugs.
• Pharmaceutical Research & Development for studying pharmacokinetics and novel drug delivery systems.
• Formulation of Solid Dosage Forms such as tablets and capsules requiring a stable salt form.
• Reference Standard in analytical laboratories for quality control and method validation.
• Preclinical Studies for investigating therapeutic efficacy and safety profiles.

Basic Information

Product Name	Calciumvalproat-Dihydrat
CAS No.	138995-18-3
Molecular Formula	C16H30CaO4·2H2O
Molecular Weight	350.50 g/mol (anhydrous basis)
Synonyms	Calcium Valproate Dihydrate; Valproate Calcium Salt Dihydrate; Calcium Divalproate Dihydrate; 2-Propylpentanoic Acid Calcium Salt Dihydrate; Calcium Dipropylacetate Dihydrate; Depakote (as the salt form); Calcium Valproic Acid Dihydrate
EINECS	Contact for details

Quality Control

Our Calciumvalproat-Dihydrat is manufactured under strict quality management systems, targeting compliance with pharmaceutical-grade standards (USP/EP). Every batch undergoes rigorous analytical testing including assay, impurity profiling, and identification. A comprehensive Certificate of Analysis (COA) is provided with each shipment to ensure traceability and meet your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation and clumping.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	9.0% - 11.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Microbiological Enumeration	Meets EP/USP criteria for non-sterile substances

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.