Description

5-Trimethylsilylthiophene-2-Boronic Acid is a high-value organoboron building block featuring both a boronic acid and a trimethylsilyl-protected thiophene moiety. This compound is essential for advanced cross-coupling reactions, particularly in the synthesis of complex heterocyclic systems and functional materials. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and organic electronics industries for constructing novel molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for forming carbon-carbon bonds between thiophene derivatives and aryl/heteroaryl halides.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs) containing thiophene cores.
• Material Science & Organic Electronics: Building block for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Agrochemical Research: Intermediate in the synthesis of novel herbicides, fungicides, and insecticides with thiophene-based structures.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts in transition metal chemistry.
• Chemical Biology & Probe Synthesis: Useful for labeling and modifying biomolecules or creating fluorescent probes due to its reactive handles.

Basic Information

Product Name	5-Trimethylsilylthiophene-2-Boronic Acid
CAS No.	138983-68-3
Molecular Formula	C9H15BO2SSi
Molecular Weight	226.19 g/mol
Synonyms	(5-Trimethylsilylthiophen-2-yl)boronic acid; 2-Borono-5-(trimethylsilyl)thiophene; 5-(Trimethylsilyl)-2-thienylboronic acid; Thiophene-2-boronic acid, 5-(trimethylsilyl)-; 5-TMS-thiophene-2-boronic acid; 5-Trimethylsilyl-2-thienylboronic Acid; 2-(5-Trimethylsilyl)thienylboronic Acid
EINECS	Contact for details

Quality Control

Our 5-Trimethylsilylthiophene-2-Boronic Acid is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality systems are designed to meet the stringent requirements of research and development as well as scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.