Description

2,3-Pyridinedicarboxylic Acid-D3 is a deuterated derivative of quinolinic acid, where three hydrogen atoms are replaced by deuterium, serving as a stable isotope-labeled internal standard. This high-purity compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry and metabolic pathway analysis. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, agrochemical, and advanced material science sectors requiring precise isotopic tracing.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled standard for the accurate quantification of quinolinic acid and related metabolites in complex biological matrices like plasma, serum, and cerebrospinal fluid.
• Neurochemical Research: Facilitates studies on the kynurenine pathway, NMDA receptor activation, and neurological disorders such as Alzheimer's disease, Huntington's disease, and depression.
• Pharmaceutical Development: Employed in pharmacokinetic (PK) and pharmacodynamic (PD) studies for drugs targeting neurological pathways, ensuring precise measurement of drug metabolites.
• Isotope Dilution Mass Spectrometry (IDMS): A key component in high-precision analytical methods for clinical diagnostics and biomarker validation.
• Metabolomics and Biomarker Discovery: Enables reliable tracking and quantification of specific metabolic fluxes in both in vitro and in vivo systems.
• Chemical Synthesis Intermediate: Acts as a specialized building block for synthesizing deuterated analogs of more complex molecules for research and development.

Basic Information

Product Name	2,3-Pyridinedicarboxylic Acid-D3
CAS No.	138946-42-6
Molecular Formula	C7D3H2NO4
Molecular Weight	170.13 g/mol
Synonyms	Quinolinic Acid-d3; 2,3-Pyridinedicarboxylic Acid-d3; Deuterated Quinolinic Acid; Pyridine-2,3-dicarboxylic Acid-d3; 2,3-Dicarboxypyridine-d3; 2,3-Pyridinedicarboxylic-2,4,5-d3 Acid; Quinolinic Acid (2,4,5-d3)
EINECS	Contact for details

Quality Control

Every batch of 2,3-Pyridinedicarboxylic Acid-D3 is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and isotopic enrichment meet the highest standards for research use. We provide comprehensive Certificates of Analysis (COA) detailing specifications for isotopic purity, chemical purity, and residual solvents. Our quality system supports compliance with relevant guidelines for stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Content)	≥ 98 atom % D
Isotopic Enrichment (MS)	≥ 99% (d3)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.