Description

tert-Butyl3-(Bromomethyl)Bicyclo[1.1.1]Pentane-1-Carboxylate is a high-value, synthetically versatile organic building block featuring the rigid and highly strained bicyclo[1.1.1]pentane (BCP) scaffold. This compound matters as a key intermediate for introducing the BCP motif into target molecules, a strategy increasingly used in medicinal chemistry to improve the physicochemical and metabolic properties of drug candidates. Pharmaceutical researchers and agrochemical developers need it to create novel compounds with enhanced potency, selectivity, and stability.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) where the bicyclo[1.1.1]pentane unit acts as a bioisostere for phenyl rings or tert-butyl groups to modulate lipophilicity and metabolic stability.
• Medicinal Chemistry & Drug Discovery: Used in fragment-based drug design and lead optimization programs to explore novel chemical space and improve drug-like properties.
• Agrochemical Research: Employed in the synthesis of novel herbicides, fungicides, or insecticides that benefit from the unique three-dimensional structure and stability of the BCP core.
• Material Science Precursor: Serves as a monomer or cross-linking agent for developing polymers with unique mechanical or thermal properties due to the strained cage structure.
• Chemical Biology Probes: Utilized to create molecular probes and tools for studying biological systems, leveraging the BCP group as a minimally perturbing label or linker.
• Academic & Contract Research: Essential reagent for synthetic methodology development and exploration of strained hydrocarbon chemistry in university and CRO laboratories.

Basic Information

Product Name	tert-Butyl3-(Bromomethyl)Bicyclo[1.1.1]Pentane-1-Carboxylate
CAS No.	138732-34-0
Molecular Formula	C12H19BrO2
Molecular Weight	275.18 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-3-(bromomethyl)bicyclo[1.1.1]pentane; tert-Butyl 3-(bromomethyl)bicyclo[1.1.1]pentane-1-carboxylate; 3-(Bromomethyl)bicyclo[1.1.1]pentane-1-carboxylic acid tert-butyl ester; BCP-Br-OtBu; Bicyclo[1.1.1]pentane, 3-(bromomethyl)-1-[(1,1-dimethylethoxy)carbonyl]-; BCP Bromomethyl Ester
EINECS	Contact for details

Quality Control

Our tert-Butyl3-(Bromomethyl)Bicyclo[1.1.1]Pentane-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic intermediates. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.