Description

3-Chloro-α-Methyl-4-(4-Ethyl-2-Thiazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial importance. This compound is a critical building block in the synthesis of advanced pharmaceutical actives, valued for its specific structural motif that imparts targeted biological activity. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the production of novel anti-inflammatory and analgesic agents.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of proprietary NSAID (Non-Steroidal Anti-Inflammatory Drug) candidates and related therapeutic molecules.
• Research & Development: Used in medicinal chemistry for structure-activity relationship (SAR) studies and the development of new anti-inflammatory compounds.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a core scaffold in multi-step synthetic routes for producing target API molecules.
• Biochemical Research: Employed as a reference standard or inhibitor in pharmacological studies targeting cyclooxygenase (COX) pathways.
• Fine Chemical Production: Utilized in the manufacture of specialized, high-value chemicals for the life sciences sector.

Basic Information

Product Name	3-Chloro-α-Methyl-4-(4-Ethyl-2-Thiazolyl)Benzeneacetic Acid
CAS No.	138568-79-3
Molecular Formula	C₁₄H₁₄ClNO₂S
Molecular Weight	295.78 g/mol
Synonyms	3-Chloro-α-methyl-4-(4-ethyl-2-thiazolyl)benzeneacetic acid; 2-[3-Chloro-4-(4-ethyl-1,3-thiazol-2-yl)phenyl]propanoic acid; α-Methyl-3-chloro-4-(4-ethyl-2-thiazolyl)benzeneacetic acid; 3-Chloro-α-methyl-4-(4-ethyl-2-thiazolyl)phenylacetic acid; Loxoprofen Impurity; Loxoprofen Related Compound; NSAID Intermediate; [3-Chloro-4-(4-ethylthiazol-2-yl)phenyl]propionic acid
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-α-Methyl-4-(4-Ethyl-2-Thiazolyl)Benzeneacetic Acid adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment. We support compliance with cGMP, ICH Q7, and other relevant pharmaceutical guidelines for intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Loss on Drying	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.