Description

3-Fluoro-α-Methyl-4-(4-Methyl-2-Thiazolyl)Benzeneacetic Acid is a high-purity, non-steroidal anti-inflammatory drug (NSAID) intermediate of significant commercial and research interest. This compound is a key building block in the synthesis of advanced pharmaceutical agents, valued for its precise molecular structure which imparts specific biological activity. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract development and manufacturing organizations (CDMOs) engaged in the development of novel therapeutic molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of potent COX-2 inhibitor class NSAIDs and other anti-inflammatory agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a core structural moiety in the research and scale-up of new chemical entities (NCEs).
• Biochemical Research: Used in pharmacological studies to investigate structure-activity relationships (SAR) and enzyme inhibition mechanisms.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling.
• Custom Synthesis: A starting material for the contract manufacturing of specialized, high-value fine chemicals and proprietary compounds.

Basic Information

Product Name	3-Fluoro-α-Methyl-4-(4-Methyl-2-Thiazolyl)Benzeneacetic Acid
CAS No.	138568-70-4
Molecular Formula	C₁₃H₁₂FNO₂S
Molecular Weight	265.30 g/mol
Synonyms	3-Fluoro-α-methyl-4-(4-methyl-2-thiazolyl)benzeneacetic acid; 2-[3-Fluoro-4-(4-methyl-1,3-thiazol-2-yl)phenyl]propanoic acid; 3-Fluoro-α-methyl-4-(4-methylthiazol-2-yl)benzeneacetic acid; 2-(3-Fluoro-4-(4-methylthiazol-2-yl)phenyl)propanoic acid; Fluorothiazolyl Phenylpropionic Acid; L-748,780 intermediate; COX-2 Inhibitor Intermediate; Anti-inflammatory Drug Intermediate
EINECS	Contact for details

Quality Control

Our 3-Fluoro-α-Methyl-4-(4-Methyl-2-Thiazolyl)Benzeneacetic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical intermediate applications. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.