Description

[(2S,3S,4R,5R)-1-Fluoro-2-Hydroxy-5-[[(3S)-3-Hydroxytetradecanoyl]Amino]-6-Oxo-4-[(3R)-3-Tetradecanoyloxytetradecanoyl]Oxy-Hexan-3-Yl]Oxyphosphonic Acid is a complex, high-purity synthetic phospholipid derivative designed for advanced research and pharmaceutical development. This compound is critical for researchers and formulators working on targeted drug delivery systems, particularly in liposomal and nanoparticle technologies. Its sophisticated structure makes it an essential building block for creating novel lipid-based carriers in oncology, vaccine development, and diagnostic imaging applications.

Application

• Liposomal Drug Formulation: A key functional excipient for constructing stable, long-circulating liposomes for chemotherapeutic and gene therapy agents.
• Nanoparticle Stabilization: Used to enhance the surface properties and biocompatibility of polymeric and lipid nanoparticles (LNPs).
• Pharmaceutical Research: Serves as a critical intermediate or active targeting ligand in the development of new Active Pharmaceutical Ingredients (APIs) and prodrugs.
• Biomembrane Studies: A valuable tool in biophysical research for modeling cell membrane interactions and studying lipid-protein dynamics.
• Diagnostic Agent Development: Employed in the synthesis of contrast agents for medical imaging techniques such as MRI and ultrasound.
• Vaccine Adjuvant Systems: Investigated for use in next-generation vaccine platforms to improve immunogenicity and delivery.

Basic Information

Product Name	[(2S,3S,4R,5R)-1-Fluoro-2-Hydroxy-5-[[(3S)-3-Hydroxytetradecanoyl]Amino]-6-Oxo-4-[(3R)-3-Tetradecanoyloxytetradecanoyl]Oxy-Hexan-3-Yl]Oxyphosphonic Acid
CAS No.	138527-42-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1-Fluoro-2-hydroxy-5-[(3S)-3-hydroxytetradecanamido]-6-oxo-4-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]oxyhexan-3-yl dihydrogen phosphate; Fluorinated phospholipid derivative; Complex phospholipid analog; Lipid-based drug delivery excipient; Phosphono lipid intermediate; CAS 138527-42-1
EINECS	Contact for details

Quality Control

Our production of this high-value phospholipid derivative adheres to stringent quality protocols suitable for pharmaceutical research and development. Each batch is characterized using advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under GMP-like conditions and can tailor specifications to meet the specific requirements of your preclinical or clinical program.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This compound is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere (argon or nitrogen).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity	≤ 1.0%
Total Impurities	≤ 5.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.