Description

tert-Butyl 8-Chloro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the isoquinoline class of compounds. This compound is of significant value for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs) and other fine chemicals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological and cardiovascular disorders.
• Organic Synthesis Building Block: Used in multi-step synthetic routes to construct complex heterocyclic frameworks for medicinal chemistry and material science.
• Agrochemical Research: Serves as a starting material for developing new pesticides and herbicides with specific biological activity.
• Chemical Reference Standard: Employed as a high-purity standard in analytical laboratories for method development and quality control.
• Academic & R&D: Utilized in university and corporate research labs for studying reaction mechanisms and exploring new chemical entities.

Basic Information

Product Name	tert-Butyl 8-Chloro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	138350-93-3
Molecular Formula	C14H16ClNO2
Molecular Weight	265.74 g/mol
Synonyms	8-Chloro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; tert-Butyl 8-chloro-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 8-Chloro-3,4-dihydro-1H-isoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-8-chloro-1,2,3,4-tetrahydroisoquinoline; 8-Chloro-2-N-Boc-1,2,3,4-tetrahydroisoquinoline; 138350-93-3; Boc-8-chloro-THIQ
EINECS	Contact for details

Quality Control

Our tert-Butyl 8-Chloro-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Meets ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.