Description

tert-Butyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a versatile and high-purity Boc-protected dihydroisoquinoline derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a protected amine functionality, enabling complex multi-step reactions in the development of sophisticated molecules. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex heterocyclic compounds and potential drug candidates targeting the central nervous system.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, leveraging the isoquinoline scaffold for biological activity.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for constructing nitrogen-containing heterocycles and natural product analogs.
• Peptidomimetics & Medicinal Chemistry: Serves as a constrained scaffold or a protected amine synthon in the design of peptide mimics and small molecule libraries.
• Material Science Precursor: Potential use in the synthesis of specialty chemicals and functionalized polymers.

Basic Information

Product Name	tert-Butyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	138350-92-2
Molecular Formula	C₁₄H₁₇NO₂
Molecular Weight	231.29 g/mol
Synonyms	1,2,3,4-Tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 2-Boc-1,2,3,4-tetrahydroisoquinoline; tert-Butyl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate; Boc-THIQ; 2-(tert-Butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-2-isoquinolinecarboxylic acid 1,1-dimethylethyl ester; 138350-92-2; tert-Butyl 3,4-dihydro-1H-isoquinoline-2-carboxylate
EINECS	Contact for details

Quality Control

Our tert-Butyl 3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to confirm identity and purity. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from strong acids and incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.