Description

2-(2-Chloro-Acetylamino)-4-p-Tolyl-Thiophene-3-Carboxylic Acid Ethyl Ester is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound serves as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where precise molecular architecture is paramount. It is primarily sought by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex thiophene-based molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Used in developing next-generation herbicides, fungicides, and insecticides that require specific thiophene scaffolds for bioactivity.
• Material Science: Building block for creating advanced organic electronic materials, such as organic semiconductors and conductive polymers.
• Chemical Synthesis: Versatile reagent for constructing complex heterocyclic compounds in academic and industrial R&D laboratories.
• Dye & Pigment Industry: Intermediate for synthesizing specialized thiophene-based dyes and colorants.

Basic Information

Item	Details
Product Name	2-(2-Chloro-Acetylamino)-4-p-Tolyl-Thiophene-3-Carboxylic Acid Ethyl Ester
CAS No.	138098-81-4
Molecular Formula	C16H16ClNO3S
Molecular Weight	337.82 g/mol
Synonyms	Ethyl 2-[(2-chloroacetyl)amino]-4-(4-methylphenyl)thiophene-3-carboxylate; 2-(2-Chloroacetamido)-4-(p-tolyl)thiophene-3-carboxylic Acid Ethyl Ester; 2-[(2-Chloroacetyl)amino]-4-(4-methylphenyl)-3-thiophenecarboxylic Acid Ethyl Ester; CAATCE; 138098-81-4; p-Tolyl Thiophene Derivative
EINECS	Contact for details

Quality Control

Our production of 2-(2-Chloro-Acetylamino)-4-p-Tolyl-Thiophene-3-Carboxylic Acid Ethyl Ester adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided with each shipment. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.