Description

(R)-2,3-Dimethyl-4-(Triphenylphosphoranylidene)-2-Butanol is a high-value chiral organophosphorus compound, primarily utilized as a specialized reagent in advanced organic synthesis. Its core value lies in its role as a key intermediate for constructing complex molecular architectures, particularly in the synthesis of biologically active molecules. This product is essential for research and development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of chiral drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Asymmetric Synthesis Reagent: Employed in stereoselective reactions, such as Wittig-type olefinations and other carbon-carbon bond-forming processes, to introduce specific chiral centers.
• Agrochemical Research: Used in the development of novel, enantiomerically pure pesticides and herbicides where biological activity is stereospecific.
• Ligand Precursor: Serves as a starting material for the preparation of chiral phosphine ligands used in transition metal catalysis.
• Fine Chemical Synthesis: Applied in the production of specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & Institutional Research: A valuable tool for methodological development in synthetic organic chemistry within university and government laboratories.

Basic Information

Product Name	(R)-2,3-Dimethyl-4-(Triphenylphosphoranylidene)-2-Butanol
CAS No.	138079-58-0
Molecular Formula	C24H25OP
Molecular Weight	360.43 g/mol
Synonyms	(R)-2,3-Dimethyl-4-(triphenyl-λ5-phosphanylidene)butan-2-ol; (R)-4-(Triphenylphosphoranylidene)-2,3-dimethyl-2-butanol; (2R)-2,3-Dimethyl-4-(triphenylphosphoranylidene)butan-2-ol; (R)-Homoallylic Alcohol Phosphonium Ylide; (R)-Wittig Reagent Intermediate; (R)-TPPB Alcohol; (R)-2-Butanol, 2,3-dimethyl-4-(triphenylphosphoranylidene)-
EINECS	Contact for details

Quality Control

Our (R)-2,3-Dimethyl-4-(Triphenylphosphoranylidene)-2-Butanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a cool, dry place. Due to its hygroscopic and easily oxidized nature, the container should only be opened in a controlled, moisture-free environment and resealed immediately after use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.