Description

1-Bromo-3-(Chloromethyl)Bicyclo[1.1.1]Pentane is a highly functionalized, strained bicyclic organic compound that serves as a valuable and versatile building block in advanced organic synthesis. Its unique bridged [1.1.1]pentane core, combined with reactive bromo and chloromethyl handles, makes it a critical intermediate for constructing complex molecular architectures with specific three-dimensional geometries. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, particularly for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially for creating bioisosteres and rigid, three-dimensional scaffolds to improve drug-like properties.
• Agrochemical Synthesis: Used in the development of new pesticides and herbicides, where the bicyclo[1.1.1]pentane structure can enhance metabolic stability and target binding.
• Materials Science Research: Building block for advanced polymers and functional materials, including high-performance resins and liquid crystals, leveraging its rigid, strained geometry.
• Chemical Biology Probes: Employed in the design of molecular probes and tags for studying biological systems due to its small, hydrophobic profile and derivatizable sites.
• Cross-Coupling Reactions: Serves as an electrophilic partner in various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce the bicyclo[1.1.1]pentane moiety.
• Ligand and Catalyst Development: Intermediate for synthesizing specialized ligands and organocatalysts with unique steric and electronic properties.

Basic Information

Item	Details
Product Name	1-Bromo-3-(Chloromethyl)Bicyclo[1.1.1]Pentane
CAS No.	137741-18-5
Molecular Formula	C7H10BrCl
Molecular Weight	209.51 g/mol
Synonyms	1-Bromo-3-(chloromethyl)bicyclo[1.1.1]pentane; 3-(Chloromethyl)-1-bromobicyclo[1.1.1]pentane; 1-Bromo-3-(chloromethyl)pentacyclo[1.1.1.11,3.01,3]pentane; BCP-Br-CH2Cl; (Chloromethyl)-1-bromobicyclo[1.1.1]pentane; 1-Bromanyl-3-(chloromethyl)bicyclo[1.1.1]pentane
EINECS	Contact for details

Quality Control

Our 1-Bromo-3-(Chloromethyl)Bicyclo[1.1.1]Pentane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including NMR, HPLC, and GC analysis, to verify identity, potency, and impurity profiles. Certificates of Analysis (COA) documenting all test results are provided with every shipment. We support cGMP compliance for advanced intermediates and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible organic solvents. The compound is light-sensitive and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.