Description

Bicyclo[1.1.1]pentane, 1-bromo-3-methyl- (9Ci) is a high-value, strained bicyclic organic building block with the CAS number 137741-15-2. This compound is prized for its unique three-dimensional structure, which imparts desirable properties in advanced material and pharmaceutical synthesis. It is primarily sought by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel molecular architectures with enhanced performance characteristics.

Application

• Pharmaceutical Intermediate: A key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in fragment-based drug discovery and for creating sp3-rich, three-dimensional scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the bicyclo[1.1.1]pentane core can improve metabolic stability and bioavailability.
• Materials Science: Serves as a precursor for advanced polymers, liquid crystals, and organic electronic materials, where its rigid, cage-like structure can modulate material properties.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Negishi) to introduce the bicyclopentyl moiety into complex molecules.
• Bioisostere Development: Acts as a valuable para-substituted benzene ring or tert-butyl group bioisostere in medicinal chemistry to optimize potency, solubility, and ADMET profiles.
• Academic & Industrial R&D: A critical reagent for methodological development in organic synthesis and for exploring new chemical space in high-throughput screening libraries.

Basic Information

Product Name	Bicyclo[1.1.1]pentane, 1-bromo-3-methyl- (9Ci)
CAS No.	137741-15-2
Molecular Formula	C6H9Br
Molecular Weight	161.04 g/mol
Synonyms	1-Bromo-3-methylbicyclo[1.1.1]pentane; 3-Methyl-1-bromobicyclo[1.1.1]pentane; 1-Bromo-3-methyl-[1.1.1]propellane; BCP-Br (Me); (3-Methylbicyclo[1.1.1]pentan-1-yl)bromide
EINECS	Contact for details

Quality Control

Our Bicyclo[1.1.1]pentane, 1-bromo-3-methyl- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical characterization, including GC, HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Typical 97-99%)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.