Description

4-Chloro-7-Methyl-5,6,7,8-Tetrahydro[1]Benzothieno[2,3-D]Pyrimidine is a high-purity, advanced pharmaceutical intermediate with the CAS number 137438-23-4. This heterocyclic compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering significant value in modern medicinal chemistry. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel therapeutic agents.

Application

This specialized intermediate serves as a key precursor in several high-value chemical synthesis pathways. Its primary applications include:

• Pharmaceutical Research & Development: A crucial scaffold for synthesizing novel drug candidates targeting various disease pathways.
• API (Active Pharmaceutical Ingredient) Manufacturing: Used in the production of complex, high-potency APIs, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization processes due to its fused benzothienopyrimidine structure.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of pharmaceutical intermediates.
• Bioconjugation & Probe Development: Potential use in creating chemical probes for biochemical and diagnostic applications.

Basic Information

Product Name	4-Chloro-7-Methyl-5,6,7,8-Tetrahydro[1]Benzothieno[2,3-D]Pyrimidine
CAS No.	137438-23-4
Molecular Formula	C12H11ClN2S
Molecular Weight	250.75 g/mol
Synonyms	4-Chloro-7-methyl-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine; 4-Chloro-7-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine; 137438-23-4; Benzothieno[2,3-d]pyrimidine, 4-chloro-5,6,7,8-tetrahydro-7-methyl-; 7-Methyl-4-chloro-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine
EINECS	Contact for details

Quality Control

Our 4-Chloro-7-Methyl-5,6,7,8-Tetrahydro[1]Benzothieno[2,3-D]Pyrimidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.