Description

Di-tert-Butyl N,n-Diisopropylphosphoramidite is a high-purity, specialized organophosphorus reagent widely used in synthetic chemistry. Its primary value lies in its role as a key intermediate for constructing complex molecules, particularly in the synthesis of oligonucleotides and other phosphorus-containing compounds. This product is essential for research and development laboratories, pharmaceutical manufacturers, and fine chemical producers engaged in advanced organic synthesis and nucleotide chemistry.

Application

• Oligonucleotide Synthesis: A critical phosphitylating agent in the solid-phase synthesis of DNA and RNA fragments.
• Phosphoramidite Intermediate: Serves as a versatile building block for the preparation of custom phosphoramidites used in automated synthesizers.
• Catalyst and Ligand Preparation: Used in the synthesis of novel phosphorus-based ligands for transition metal catalysis.
• Pharmaceutical Intermediate: Employed in the research and production of active pharmaceutical ingredients (APIs) containing phosphorus centers.
• Material Science: A precursor for creating phosphorus-modified polymers and advanced materials.
• Agrochemical Research: Utilized in the development of new crop protection agents and herbicides.

Basic Information

Product Name	Di-tert-Butyl N,n-Diisopropylphosphoramidite
CAS No.	137348-86-8
Molecular Formula	C14H32NO2P
Molecular Weight	277.39 g/mol
Synonyms	Di-tert-butyl diisopropylphosphoramidite; N,N-Diisopropyl-P,P-di-tert-butylphosphoramidous diamide; Di-tert-butyl N,N-diisopropylphosphoramidite; Phosphoramidous diamide, N,N-diisopropyl-P,P-di-tert-butyl-; tert-Butyl N,N-diisopropylphosphoramidite; Diisopropylamino-di-tert-butoxyphosphine
EINECS	Contact for details

Quality Control

Our Di-tert-Butyl N,n-Diisopropylphosphoramidite is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. We adhere to current Good Manufacturing Practices (cGMP) where applicable. Comprehensive analytical testing, including NMR and HPLC, is performed to verify identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) in a cool, dry place at 2-8°C to maintain stability. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air or moisture must be avoided to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.