Description

(Z)-2-(((1-(tert-Butoxy)-2-Methyl-1-Oxopropan-2-Yl)Oxy)Imino)-2-(2-((tert-Butoxycarbonyl)Amino)Thiazol-4-Yl)Acetic acid is a sophisticated, high-purity chemical intermediate featuring a protected amino-thiazole acetic acid core. This compound is critical for the synthesis of advanced pharmaceutical agents, particularly in the development of β-lactam antibiotics, where it serves as a key building block for side-chain construction. It is primarily utilized by research institutions, fine chemical manufacturers, and pharmaceutical companies engaged in the development and production of novel antibacterial drugs and other complex organic molecules.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of advanced cephalosporin and penicillin antibiotic derivatives.
• Active Pharmaceutical Ingredient (API) Development: Serves as a protected synthon for constructing the complex side-chains of β-lactam antibiotics during R&D and scale-up.
• Fine Chemical Synthesis: Used in organic synthesis for the introduction of the (aminothiazol-4-yl)glyoxylic acid moiety into target molecules.
• Bioconjugation & Proteomics Research: The reactive carboxylic acid and protected amine groups make it suitable for designing linkers and probes in biochemical research.
• Process Chemistry & Route Scouting: Employed by process chemists to develop and optimize scalable manufacturing routes for final drug substances.

Basic Information

Product Name	(Z)-2-(((1-(tert-Butoxy)-2-Methyl-1-Oxopropan-2-Yl)Oxy)Imino)-2-(2-((tert-Butoxycarbonyl)Amino)Thiazol-4-Yl)Acetic acid
CAS No.	137088-65-4
Molecular Formula	C19H29N3O7S
Molecular Weight	443.52 g/mol
Synonyms	(Z)-2-(2-((tert-Butoxycarbonyl)amino)thiazol-4-yl)-2-(((2-(tert-butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)acetic acid; 2-(((1-(tert-Butoxy)-2-methyl-1-oxopropan-2-yl)oxy)imino)-2-(2-((tert-butoxycarbonyl)amino)-1,3-thiazol-4-yl)acetic acid; (Z)-Boc-Amino-Thiazol-4-yl-glyoxylic acid O-tert-butyl ester oxime; tert-Butyl (Z)-2-(2-((tert-butoxycarbonyl)amino)thiazol-4-yl)-2-((tert-butoxycarbonyl)oxyimino)acetate derivative; 137088-65-4; Cefixime intermediate derivative; Protected ATG acid derivative.
EINECS	Contact for details

Quality Control

Our production of this high-value intermediate adheres to strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with customer specifications and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.