Description

D-[5-2H]Glucose CAS NO 136864-16-9 is a stable isotope-labeled analog of D-glucose, specifically deuterated at the 5-position. This compound is an essential tool for metabolic research, enabling precise tracing and quantification of glucose utilization pathways in biological systems. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and academic sectors for advanced studies in metabolism, drug development, and diagnostic assay development.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway rates in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS and GC-MS assays for the accurate bioanalysis of glucose and related metabolites in preclinical and clinical studies.
• In Vitro Diagnostic (IVD) Development: Employed in the calibration and validation of mass spectrometry-based clinical diagnostic tests for metabolic disorders like diabetes.
• Biochemical Research: Facilitates the study of glycolysis, gluconeogenesis, the pentose phosphate pathway, and other central carbon metabolic processes.
• Stable Isotope Labeling: Acts as a precursor for the synthesis of other deuterated metabolites or complex biomolecules for research purposes.

Basic Information

Item	Detail
Product Name	D-[5-2H]Glucose
CAS No.	136864-16-9
Molecular Formula	C6H11DO6
Molecular Weight	181.16 g/mol
Synonyms	5-Deuterio-D-glucose; D-Glucose-5-d; [5-2H]Glucose; Deuterated D-glucose; D-Glucose (5-2H); Stable Isotope-Labeled Glucose; Glucose-d1; 136864-16-9
EINECS	Contact for details

Quality Control

Every batch of D-[5-2H]Glucose is produced and analyzed under strict quality management protocols. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and Mass Spectrometry for structural confirmation and isotopic enrichment verification. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, assay, and specific analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % 2H
Chemical Purity (Titration)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Specific Optical Rotation	+52.5° to +53.0° (c=10 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.