Description

Temazepam-D5 is a deuterium-labeled analog of the benzodiazepine derivative temazepam, specifically designed for use as an internal standard in analytical chemistry. This high-purity compound is essential for ensuring the accuracy and reliability of quantitative analyses, particularly in complex biological matrices. It is a critical tool for pharmaceutical research, forensic toxicology, and clinical laboratories conducting drug metabolism and pharmacokinetic (DMPK) studies.

Application

• Internal Standard for LC-MS/MS: Primary application for the precise quantification of temazepam and its metabolites in bioanalytical assays.
• Pharmaceutical R&D: Used in drug metabolism and pharmacokinetic (DMPK) studies to track absorption, distribution, metabolism, and excretion.
• Forensic Toxicology: Enables accurate measurement of temazepam in blood, urine, or tissue samples for legal and medical investigations.
• Clinical Research: Supports studies on drug efficacy, therapeutic drug monitoring (TDM), and patient compliance.
• Reference Material: Serves as a certified reference material (CRM) for method development, validation, and laboratory quality control.
• Isotope Dilution Mass Spectrometry (IDMS): Employed in high-precision analytical techniques to achieve superior accuracy in quantitative results.

Basic Information

Product Name	Temazepam-D5
CAS No.	136765-51-0
Molecular Formula	C16H8D5ClN2O2
Molecular Weight	295.78 g/mol
Synonyms	7-Chloro-1,3-dihydro-3-hydroxy-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one-d5; Temazepam (methyl-d3, phenyl-d2); Temazepam-d5; Deuterated Temazepam; [2H5]-Temazepam; 3-Hydroxydiazepam-d5; Restoril-d5 (labeled)
EINECS	Contact for details

Quality Control

Every batch of Temazepam-D5 is manufactured and tested to meet the stringent requirements for analytical reference standards. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure high chemical purity and isotopic enrichment. Certificates of Analysis (COA) detailing lot-specific results for assay, isotopic purity, and identity are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98 atom % D
Chemical Purity	≥ 95%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.