Description

Nortriptyline-D3 Hydrochloride is a deuterium-labeled analog of the tricyclic antidepressant nortriptyline, where three hydrogen atoms are replaced by deuterium. This stable isotope-labeled compound is essential as an internal standard in quantitative bioanalytical methods, ensuring the highest accuracy and reliability in mass spectrometry-based analyses. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and forensic toxicology labs engaged in drug metabolism, pharmacokinetic (PK/ADME) studies, and therapeutic drug monitoring.

Application

• Internal Standard for LC-MS/MS: Critical for the precise quantification of nortriptyline in biological matrices (plasma, serum, urine) during bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK): Used in absorption, distribution, metabolism, and excretion (ADME) studies to track and measure the parent drug and its metabolites.
• Therapeutic Drug Monitoring (TDM): Enables accurate measurement of nortriptyline levels in patient samples to optimize dosage and ensure therapeutic efficacy while minimizing side effects.
• Forensic and Clinical Toxicology: Supports the confirmatory analysis of nortriptyline in cases of overdose, poisoning, or compliance testing.
• Pharmaceutical Impurity Profiling: Can be utilized as a reference standard in the analysis of deuterated drug substances and related impurities.
• Isotope Dilution Mass Spectrometry (IDMS): Serves as the ideal spike-in standard for this highly accurate absolute quantification technique.

Basic Information

Product Name	Nortriptyline-D3 Hydrochloride
CAS No.	136765-48-5
Molecular Formula	C19H18D3ClN
Molecular Weight	299.86 g/mol
Synonyms	Nortriptyline-d3 HCl; 10,11-Dihydro-N-methyl-5H-dibenzo[a,d]cycloheptene-δ5,γ-propylamine-3,3,5,5-d4 Hydrochloride; 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methyl-1-propanamine-d3 Hydrochloride; 5-(3-Methylaminopropylidene)-10,11-dihydro-5H-dibenzo[a,d]cycloheptene-d3 Hydrochloride; Nortriptyline (methyl-d3) Hydrochloride; Deuterated Nortriptyline Hydrochloride
EINECS	Contact for details

Quality Control

Our Nortriptyline-D3 Hydrochloride is manufactured under controlled conditions to ensure exceptional isotopic purity and chemical integrity, meeting the stringent requirements of analytical reference standard applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (typically ≥98% D), chemical purity (by HPLC), and identity confirmation (by NMR and MS). We adhere to a rigorous quality management system, and COAs are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (MS)	≥98 atom % D
Chemical Purity (by HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.