Description

Clomipramine-D3 is a deuterated internal standard of the tricyclic antidepressant clomipramine, specifically designed for analytical applications. This stable isotope-labeled compound is essential for ensuring the accuracy and reliability of quantitative mass spectrometry analyses. It is primarily used by pharmaceutical R&D laboratories, contract research organizations (CROs), and regulatory testing facilities for method development, validation, and bioanalytical studies.

Application

• Quantitative Bioanalysis: Serves as a critical internal standard for the precise measurement of clomipramine in biological matrices (plasma, serum, urine) using LC-MS/MS and GC-MS.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in clinical and preclinical research.
• Therapeutic Drug Monitoring (TDM): Used in assay development to monitor clomipramine levels in patient samples, aiding in dose optimization and safety.
• Forensic and Toxicology Testing: Provides a reliable reference for the confirmatory identification and quantification of clomipramine in forensic investigations.
• Drug Metabolism and Stability Studies: Facilitates research into the metabolic pathways and stability profile of the parent drug.
• Quality Control in Pharmaceutical Manufacturing: Supports impurity profiling and assay validation for clomipramine active pharmaceutical ingredient (API) and finished dosage forms.

Basic Information

Product Name	Clomipramine-D3
CAS No.	136765-29-2
Molecular Formula	C19H20D3ClN2
Molecular Weight	318.87 g/mol
Synonyms	3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenzo[b,f]azepine-d3; Clomipramine-d3; 3-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N,N-dimethylpropan-1-amine-d3; Anafranil-d3; Deuterated Clomipramine; Clomipramine Internal Standard; Clomipramine-d3 (methyl-d3)
EINECS	Contact for details

Quality Control

Every batch of Clomipramine-D3 is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical and isotopic purity, supported by a detailed Certificate of Analysis (COA) for each lot. Our quality protocols are designed to meet the stringent requirements of pharmaceutical reference standard applications, ensuring data integrity for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (deuterium)	≥ 99.0 atom % D
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.