Description

[S-(R*,R*)]-3-Amino-2-Hydroxy-Propanoic-2,3-D2 Acid is a high-purity, deuterium-labeled derivative of serine, a critical amino acid. This compound is specifically designed for advanced research and development applications where isotopic labeling is essential for precise analytical tracking and metabolic studies. It is primarily utilized by pharmaceutical researchers, analytical chemists, and isotope specialists in drug discovery, metabolic pathway analysis, and as a sophisticated building block for labeled peptides and complex organic molecules.

Application

• Isotopic Tracer in Metabolic Studies: Used in mass spectrometry (MS) and nuclear magnetic resonance (NMR) to trace biochemical pathways and drug metabolism with high precision.
• Pharmaceutical Research & Drug Discovery: Serves as a key deuterated intermediate for synthesizing isotopically labeled drug candidates to improve pharmacokinetic profiles (Deuterium Kinetic Isotope Effect).
• Analytical Reference Standard: Provides a critical standard for quantitative analysis, method development, and validation in bioanalytical and environmental testing laboratories.
• Biochemical Research: Employed in enzymology and protein studies to investigate mechanisms involving serine proteases and other serine-dependent biological processes.
• Synthesis of Labeled Peptides & Proteins: Acts as a building block for the solid-phase or solution-phase synthesis of deuterium-labeled peptides for structural biology research.
• Advanced Material Science: Potential use in the development of specialized polymers and materials where isotopic labeling affects physical or spectroscopic properties.

Basic Information

Product Name	[S-(R*,R*)]-3-Amino-2-Hydroxy-Propanoic-2,3-D2 Acid
CAS No.	136743-38-9
Molecular Formula	C₃H₅D₂NO₃
Molecular Weight	107.11 g/mol
Synonyms	(2S,3R)-2-Amino-3-hydroxypropanoic-2,3-d2 acid; L-Serine-2,3-d2; (S)-2-Amino-3-hydroxypropionic-2,3-d2 acid; Deuterated L-Serine; [2,3-²H₂]-L-Serine; (2S,3R)-Serine-2,3-d2; 3-Amino-2-hydroxypropanoic-2,3-d2 acid
EINECS	Contact for details

Quality Control

Our [S-(R*,R*)]-3-Amino-2-Hydroxy-Propanoic-2,3-D2 Acid is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chemical purity (by HPLC), isotopic enrichment (by MS or NMR), chiral purity, and residual solvent content. We adhere to cGMP principles for advanced intermediates and can provide material tailored to specific pharmacopeial or internal specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under dry, inert conditions (e.g., nitrogen or argon atmosphere) when opening the primary container to prevent degradation and ensure long-term stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and deuterium labeling pattern
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.