Description

1H-Indole-2-Propanoic Acid, 1-[(4-Chlorophenyl)Methyl]-3-[(1,1-Dimethylethyl)Thio]-α,α-Dimethyl-5-(2-Quinolinylmethoxy)-, Methyl Ester is a sophisticated, high-purity synthetic intermediate characterized by its unique indole-quinoline hybrid structure. This compound is critical for research and development in advanced pharmaceutical synthesis, particularly for targeting specific biological pathways. It is primarily sought by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Biochemical Research: Used as a reference standard or probe molecule in enzymatic and receptor binding studies due to its complex heterocyclic structure.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.
• Contract Research Organizations (CROs): Supplied to CROs for client-sponsored drug discovery and development programs.

Basic Information

Product Name	1H-Indole-2-Propanoic Acid, 1-[(4-Chlorophenyl)Methyl]-3-[(1,1-Dimethylethyl)Thio]-α,α-Dimethyl-5-(2-Quinolinylmethoxy)-, Methyl Ester
CAS No.	136694-18-3
Molecular Formula	C35H37ClN2O3S
Molecular Weight	601.20 g/mol
Synonyms	Methyl 1-[(4-chlorophenyl)methyl]-3-(tert-butylthio)-α,α-dimethyl-5-(quinolin-2-ylmethoxy)-1H-indole-2-propanoate; L-754,394 (potential research code); 1-[(4-Chlorobenzyl)-3-(tert-butylthio)-α,α-dimethyl-5-(2-quinolinylmethoxy)-1H-indole-2-propanoic Acid Methyl Ester; Tert-Butyl 5-(2-Quinolinylmethoxy)-1-[(4-chlorophenyl)methyl]-α,α-dimethyl-1H-indole-2-propanoate Thioether; CAS 136694-18-3
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to comprehensive analytical profiling using HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting critical parameters. We support development and commercial projects with quality standards suitable for cGMP compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound may be light-sensitive; prolonged exposure to light should be avoided. Keep container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.