Description

Quiflapon is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP), a key enzyme in the leukotriene biosynthesis pathway. This mechanism of action makes it a critical research tool for investigating inflammatory and allergic responses. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel therapeutics for conditions like asthma, atherosclerosis, and other leukotriene-mediated diseases. The compound is supplied to ensure high purity and batch-to-batch consistency for reliable experimental results.

Application

• Pharmaceutical Research & Development: A key reference standard and biochemical tool for studying the 5-lipoxygenase pathway and screening new anti-inflammatory drug candidates.
• Inflammation Biology Studies: Used in in vitro and in vivo models to elucidate the role of leukotrienes in various inflammatory diseases.
• Respiratory Disease Research: Critical for investigating potential therapeutic targets for asthma, allergic rhinitis, and chronic obstructive pulmonary disease (COPD).
• Cardiovascular Research: Applied in studies exploring the contribution of inflammation to atherosclerosis and myocardial infarction.
• Biochemical Assay Development: Serves as a control compound in high-throughput screening (HTS) assays designed to discover FLAP inhibitors.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental pharmacological and immunological studies.

Basic Information

Product Name	Quiflapon
CAS No.	136668-42-3
Molecular Formula	C31H23F3N2O4S
Molecular Weight	576.59 g/mol
Synonyms	MK-0591; 3-[1-(4-Chlorobenzyl)-3-(t-butylthio)-5-(quinolin-2-yl-methoxy)indol-2-yl]-2,2-dimethylpropanoic Acid; L-674,636; FLAP Inhibitor MK-0591; Quiflapon sodium salt (hydrate); 5-Lipoxygenase-Activating Protein Inhibitor
EINECS	Contact for details

Quality Control

Our Quiflapon is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We support cGMP standards for active pharmaceutical ingredient (API) development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm
Assay	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.