Description

(3S,4As,8As)-2-Carbobenzyloxy-Decahydro-3-Isoquinolinecarboxylic Acid is a sophisticated chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. Its value lies in its stereochemically defined structure, which is critical for constructing complex molecules with high enantiomeric purity. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in the development of peptidomimetics, active pharmaceutical ingredients (APIs), and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of complex drug candidates, particularly those targeting neurological and cardiovascular diseases.
• Peptidomimetics Research: Used to construct non-natural peptide analogs with enhanced metabolic stability and bioavailability for therapeutic applications.
• Asymmetric Synthesis: Serves as a versatile building block for introducing the decahydroisoquinoline scaffold in stereoselective chemical transformations.
• API Development: Employed in the research and process development stages for creating novel Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-protein interactions.
• Custom Synthesis & Contract Manufacturing: A critical starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Item	Detail
Product Name	(3S,4As,8As)-2-Carbobenzyloxy-Decahydro-3-Isoquinolinecarboxylic Acid
CAS No.	136465-85-5
Molecular Formula	C18H23NO4
Molecular Weight	317.38 g/mol
Synonyms	(3S,4aS,8aS)-2-(((Benzyloxy)carbonyl)amino)decahydroisoquinoline-3-carboxylic Acid; (3S,4aS,8aS)-2-(Cbz-amino)decahydro-3-isoquinolinecarboxylic Acid; Cbz-DHIQ-OH; N-Carbobenzyloxy-decahydroisoquinoline-3-carboxylic Acid; (3S,4aS,8aS)-1,2,3,4,4a,5,6,7,8,8a-Decahydro-2-[[(phenylmethoxy)carbonyl]amino]-3-isoquinolinecarboxylic Acid; Z-DHIQ-OH; Nα-Cbz-(3S,4aS,8aS)-decahydroisoquinoline-3-carboxylic Acid
EINECS	Contact for details

Quality Control

Our (3S,4As,8As)-2-Carbobenzyloxy-Decahydro-3-Isoquinolinecarboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) with comprehensive HPLC, NMR, and optical rotation data are provided to guarantee consistent quality, identity, and purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. For long-term storage, consider storing at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.