Description

1H-1-Benzazepine-3-Carboxamide, 2,3,4,5-Tetrahydro-2-Methoxy-1,3,5-Trimethyl-n-Phenyl-, (2R,3R,5R)-Rel- is a high-purity, stereochemically defined benzazepine derivative of significant interest in advanced organic synthesis. This compound serves as a critical chiral building block and a sophisticated scaffold for pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and complex molecular probes.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of potential therapeutic agents targeting central nervous system (CNS) disorders.
• Medicinal Chemistry Research: Used as a core scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Process Chemistry Development: Serves as a critical intermediate for optimizing synthetic routes and scaling up production of complex molecules.
• Asymmetric Synthesis: Employed as a chiral auxiliary or building block in stereoselective synthesis to create enantiomerically pure compounds.
• Biochemical Research: Utilized in the development of molecular probes and ligands for studying receptor binding and enzyme inhibition.
• Fine Chemical Production: A high-value intermediate for the manufacture of specialty chemicals requiring a defined benzazepine structure.

Basic Information

Product Name	1H-1-Benzazepine-3-Carboxamide, 2,3,4,5-Tetrahydro-2-Methoxy-1,3,5-Trimethyl-n-Phenyl-, (2R,3R,5R)-Rel-
CAS No.	136463-67-7
Molecular Formula	C20H24N2O2
Molecular Weight	324.42 g/mol
Synonyms	Rel-(2R,3R,5R)-2,3,4,5-Tetrahydro-2-methoxy-1,3,5-trimethyl-N-phenyl-1H-1-benzazepine-3-carboxamide; (2R,3R,5R)-2-Methoxy-1,3,5-trimethyl-N-phenyl-2,3,4,5-tetrahydro-1H-1-benzazepine-3-carboxamide; Benzazepine-3-carboxamide derivative; 1H-1-Benzazepine-3-carboxamide, 2,3,4,5-tetrahydro-2-methoxy-1,3,5-trimethyl-N-phenyl-, (2R,3R,5R)-rel-; 136463-67-7; UNII-9K5J8QK0VW
EINECS	Contact for details

Quality Control

Our 1H-1-Benzazepine-3-Carboxamide, 2,3,4,5-Tetrahydro-2-Methoxy-1,3,5-Trimethyl-n-Phenyl-, (2R,3R,5R)-Rel- is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure high chemical and isomeric purity suitable for research and development applications. Comprehensive Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). Keep the container tightly sealed in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (sum of (2R,3R,5R) isomers)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.