Description

Biphenyldiisopropylsilyl Chloride is a specialized organosilicon reagent primarily used as a versatile protecting group agent in advanced organic synthesis. Its value lies in providing steric bulk and stability, enabling selective transformations in complex molecule construction. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for the synthesis of active pharmaceutical ingredients (APIs) and novel chemical entities.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing the biphenyldiisopropylsilyl (BDIPS) protecting group for alcohols and other functional groups during multi-step API synthesis.
• Agrochemical Research & Development: Used in the creation of novel pesticide and herbicide candidates where selective protection/deprotection strategies are required.
• Advanced Material Precursor: Serves as a building block in the synthesis of silicon-containing polymers, dendrimers, and liquid crystals for electronic and optical applications.
• Peptide and Oligonucleotide Chemistry: Employed for the temporary protection of sensitive hydroxyl groups in solid-phase and solution-phase synthesis of biomolecules.
• Catalyst and Ligand Development: Utilized to modify catalysts and chiral ligands to fine-tune their steric and electronic properties for asymmetric catalysis.
• Process Chemistry & Scale-up: Applied in pilot plant and manufacturing settings for the robust, large-scale production of complex organic molecules.

Basic Information

Item	Detail
Product Name	Biphenyldiisopropylsilyl Chloride
CAS No.	136449-55-3
Molecular Formula	C18H23ClSi
Molecular Weight	302.91 g/mol
Synonyms	BDIPS-Cl; Biphenyl-4,4'-diylbis(1-methylethyl)silylene Chloride; Diisopropylbiphenylsilyl Chloride; 4,4'-Diisopropylsilylbiphenyl Chloride; (Biphenyl-4,4'-diyl)bis(propan-2-yl)silane Chloride; Chlorodiisopropylbiphenylsilane
EINECS	Contact for details

Quality Control

Our Biphenyldiisopropylsilyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.