Description

I-Peg6-Oh CAS NO 136399-07-0 is a high-purity, monodisperse polyethylene glycol (PEG) derivative featuring a terminal hydroxyl group and an isopropylidene-protected backbone. This compound is a critical intermediate for creating precisely defined, functionalized PEG linkers used in advanced bioconjugation and pharmaceutical development. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require controlled PEGylation to enhance the pharmacokinetic properties of therapeutic agents, such as proteins, peptides, and small molecule drugs.

Application

• Pharmaceutical PEGylation: A key building block for synthesizing heterobifunctional PEG linkers to conjugate drugs, proteins, or targeting ligands, improving solubility, stability, and circulation half-life.
• Bioconjugation Reagent Synthesis: Used to create custom crosslinkers and spacers for attaching fluorescent dyes, biotin, or other functional groups to biomolecules.
• ADC (Antibody-Drug Conjugate) Development: Serves as a component in the construction of cleavable or non-cleavable linkers that connect cytotoxic payloads to antibodies.
• Polymer Chemistry: Acts as a monofunctional initiator or monomer for the synthesis of well-defined block copolymers and functionalized polymeric materials.
• Diagnostic Assay Development: Employed to modify surfaces or nanoparticles to reduce non-specific binding and improve assay performance.
• Drug Delivery System Fabrication: Incorporated into the design of micelles, liposomes, and dendrimers to create stealth properties and controlled release profiles.

Basic Information

Item	Detail
Product Name	I-Peg6-Oh
CAS No.	136399-07-0
Molecular Formula	C17H34O8
Molecular Weight	366.45 g/mol
Synonyms	1,1-Dimethylethyl 2,2-dimethyl-3,6,9,12,15,18-hexaoxa-4,4-docosanedioate; 2,2-Dimethyl-3,6,9,12,15,18-hexaoxahenicosan-21-ol, 1,1-dimethylethyl ester; tert-Butyl-PEG6-OH; Isopropylidene-protected Hexaethylene Glycol; Monomethoxy PEG6 tert-butyl ester (related); Acetal-PEG6-OH; Heterobifunctional PEG Acetal; (2,2-Dimethyl-1,3-dioxolan-4-yl)methyl-PEG5-OH
EINECS	Contact for details

Quality Control

Every batch of I-Peg6-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and mass spectrometry analysis. Our quality commitment supports applications in GMP and cGMP environments where material traceability and specification adherence are paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere to prevent potential oxidation.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.