Description

Buprenorphine CAS NO 136232-82-1 is a potent semi-synthetic opioid analgesic with partial agonist activity at the mu-opioid receptor. It is a critical active pharmaceutical ingredient (API) valued for its unique pharmacological profile, offering effective pain management with a reduced risk of respiratory depression and abuse potential compared to full agonists. This compound is essential for pharmaceutical manufacturers developing sublingual tablets, transdermal patches, and injectable formulations for the treatment of moderate to severe chronic pain and opioid use disorder.

Application

• Pharmaceutical API: Primary ingredient in the manufacture of sublingual and buccal tablets for pain management and medication-assisted treatment (MAT).
• Transdermal Drug Delivery: Key component in the production of transdermal patches providing sustained, long-term analgesic delivery.
• Injectable Formulations: Used in parenteral solutions for hospital-based acute and post-operative pain control.
• Opioid Dependence Therapy: Core API in combination products (e.g., with naloxone) for the treatment of opioid addiction.
• Research & Development: Reference standard and building block in pharmacological research and the development of novel analgesic agents.
• Veterinary Medicine: Employed in controlled veterinary applications for managing severe pain in animals.

Basic Information

Product Name	Buprenorphine
CAS No.	136232-82-1
Molecular Formula	C29H41NO4
Molecular Weight	467.65 g/mol
Synonyms	Buprenorphine Hydrochloride; BPN; NIH 8805; UM-952; (2S)-2-[17-Cyclopropylmethyl-4,5α-epoxy-3-hydroxy-6-methoxy-6α,14-ethano-14α-morphinan-7α-yl]-3,3-dimethylbutan-2-ol; 21-Cyclopropyl-7α-[(S)-1-hydroxy-1,2,2-trimethylpropyl]-6,14-endo-ethano-6,7,8,14-tetrahydrooripavine
EINECS	Contact for details

Quality Control

Our Buprenorphine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with pharmacopeial standards (e.g., USP, EP). A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with your requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.