Description

Arofylline CAS NO 136145-07-8 is a high-purity pharmaceutical intermediate and research chemical belonging to the xanthine derivative class. This compound is valued for its role as a key building block in the synthesis of advanced therapeutic agents, particularly those targeting respiratory and inflammatory pathways. It is essential for R&D laboratories and manufacturing facilities in the pharmaceutical and biotechnology sectors seeking reliable, high-quality raw materials for drug development and production.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of novel adenosine receptor antagonists and phosphodiesterase (PDE) inhibitors.
• Respiratory Drug Research: Key precursor in the development of potential therapeutics for asthma, chronic obstructive pulmonary disease (COPD), and other pulmonary conditions.
• Anti-inflammatory Agent Development: Serves as a core structure for creating compounds with targeted anti-inflammatory activity.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies and enzyme inhibition assays.
• Academic & Contract Research: Employed in university and CRO settings for medicinal chemistry programs and mechanism-of-action studies.

Basic Information

Product Name	Arofylline
CAS No.	136145-07-8
Molecular Formula	C13H16N6O3
Molecular Weight	304.31 g/mol
Synonyms	8-Benzyl-1,3-dipropylxanthine; 8-Benzyl-1,3-dipropyl-3,7-dihydro-1H-purine-2,6-dione; 1,3-Dipropyl-8-benzylxanthine; BDPX; Arofylline (INN); UNII-2J4Q6Q2B8T
EINECS	Contact for details

Quality Control

Our Arofylline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.