Description

Hexamethyl-D18-Disilazane is a deuterated organosilicon compound, specifically the perdeuterated isotopologue of hexamethyldisilazane (HMDS). This high-purity, isotopically labeled reagent is critical for applications requiring minimal interference from proton signals, such as advanced NMR spectroscopy and mechanistic studies. It is primarily utilized by research institutions, analytical laboratories, and specialty chemical manufacturers in the pharmaceutical, agrochemical, and materials science sectors for precise molecular analysis and as a derivatization agent.

Application

• NMR Spectroscopy Solvent & Reagent: Used as a deuterated solvent or chemical shift reference standard in nuclear magnetic resonance (NMR) to eliminate background proton signals.
• Deuterium Labeling Studies: Serves as a source of deuterium atoms in synthetic chemistry for reaction mechanism elucidation and kinetic isotope effect (KIE) studies.
• Silylation Agent for Sensitive Analytics: Acts as a derivatization reagent in gas chromatography (GC) and mass spectrometry (MS) for analyzing compounds with active hydrogens, such as alcohols, phenols, and carboxylic acids.
• Surface Modification & Silanization: Employed to introduce hydrophobic, deuterated trimethylsilyl groups onto silica, glass, or other oxide surfaces in materials research.
• Precursor for Deuterated Silicones: Used in the synthesis of specialty deuterated silicone polymers and fluids for research in polymer physics and diffusion studies.
• Pharmaceutical Intermediate: Utilized in the synthesis of deuterated active pharmaceutical ingredients (APIs) for metabolic and pharmacokinetic research.

Basic Information

Product Name	Hexamethyl-D18-Disilazane
CAS No.	136068-19-4
Molecular Formula	C6D18NSi2
Molecular Weight	164.48 g/mol
Synonyms	Perdeuteriohexamethyldisilazane; HMDS-d18; 1,1,1,3,3,3-Hexadeuterio-2-(trimethylsilyl)-1,3-bis(trimethylsilyl)amine; Bis(trimethylsilyl)amine-d18; Deuterated Hexamethyldisilazane; Hexamethyldisilazane-d18; (N,N-Bis(trimethylsilyl)amine)-d18; Deuterated HMDS
EINECS	Contact for details

Quality Control

Our Hexamethyl-D18-Disilazane is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity. Each batch undergoes rigorous analytical testing, including NMR, GC-MS, and Karl Fischer titration, to confirm deuterium enrichment, chemical identity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing isotopic purity (e.g., D atom %), chemical assay, and specific tests is provided with every shipment to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Due to its hygroscopic and highly volatile nature, containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent moisture absorption and decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Deuterium Enrichment (Atom % D)	≥ 98% (by 1H NMR)
Assay (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.