Description

(R)-4,4,4-Trifluorobutane-1,3-Diol CAS NO 135859-36-8 is a high-purity chiral fluorinated building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of a stereogenic center and a trifluoromethyl group, which is crucial for modulating the physicochemical and metabolic properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for creating novel active ingredients with enhanced potency and stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of fluorinated active pharmaceutical ingredients (APIs), especially in oncology and central nervous system (CNS) drug discovery.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the fluorine moiety improves biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the creation of specialty fluorinated polymers and liquid crystals with unique optical and electronic properties.
• Peptidomimetics and Bioisosteres: The diol functionality and fluorine atoms make it valuable for designing peptide mimics and bioisosteric replacements in medicinal chemistry.

Basic Information

Product Name	(R)-4,4,4-Trifluorobutane-1,3-Diol
CAS No.	135859-36-8
Molecular Formula	C4H7F3O2
Molecular Weight	144.09 g/mol
Synonyms	(R)-4,4,4-Trifluoro-1,3-butanediol; (R)-1,3-Dihydroxy-4,4,4-trifluorobutane; (3R)-4,4,4-Trifluorobutane-1,3-diol; (R)-TFBD; (R)-Trifluorobutane Diol; (R)-4,4,4-Trifluorobutane Diol; (R)-1,3-Butanediol, 4,4,4-trifluoro-
EINECS	Contact for details

Quality Control

Our (R)-4,4,4-Trifluorobutane-1,3-Diol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and enantiomeric purity, meeting the exacting standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC/GC), chiral purity, and residual solvent content is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.