Description

3-(Pyrrolidin-1-Ylcarbonyl)-1,2,3,4-Tetrahydroisoquinoline is a high-purity, advanced pharmaceutical intermediate with the CAS registry number 135709-66-9. This compound is valued for its role as a critical building block in the synthesis of complex bioactive molecules, offering researchers and manufacturers a reliable and well-characterized starting material. It is primarily utilized by the pharmaceutical and biotechnology industries for the research and development of new therapeutic agents, particularly in central nervous system (CNS) and oncology drug discovery programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly for neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in high-throughput screening and structure-activity relationship (SAR) studies to optimize lead compounds.
• API Synthesis: Serves as a core scaffold in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs).
• Biochemical Research: Employed as a tool compound in pharmacological assays to study receptor interactions and enzyme inhibition.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Academic Research: Utilized in university and institutional labs for exploratory organic synthesis and methodological development.

Basic Information

Product Name	3-(Pyrrolidin-1-Ylcarbonyl)-1,2,3,4-Tetrahydroisoquinoline
CAS No.	135709-66-9
Molecular Formula	C₁₄H₁₈N₂O
Molecular Weight	230.31 g/mol
Synonyms	1,2,3,4-Tetrahydro-3-(1-pyrrolidinylcarbonyl)isoquinoline; 3-(1-Pyrrolidinylcarbonyl)-1,2,3,4-tetrahydroisoquinoline; 3-(Pyrrolidine-1-carbonyl)-1,2,3,4-tetrahydroisoquinoline; 135709-66-9; Tetrahydroisoquinoline-3-carboxylic acid pyrrolidide; 3-Carbamoyl-1,2,3,4-tetrahydroisoquinoline, N-pyrrolidinyl derivative
EINECS	Contact for details

Quality Control

Our 3-(Pyrrolidin-1-Ylcarbonyl)-1,2,3,4-Tetrahydroisoquinoline is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom synthesis to meet specific pharmacopeial or client specifications is available.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (typically 15-25°C). The material may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.