Description

(R)-Salmeterol 1-Hydroxy-2-Naphthoic Acid Salt CAS NO 135271-49-7 is a high-purity, enantiomerically pure salt form of the long-acting β-2 adrenergic receptor agonist, Salmeterol. This specific (R)-enantiomer is a critical advanced pharmaceutical intermediate for the development of novel, potent bronchodilators targeting respiratory conditions. It is essential for pharmaceutical R&D, process chemistry, and the synthesis of active pharmaceutical ingredients (APIs) for inhalation therapies. Our supply guarantees the stringent purity and chiral integrity required for preclinical and clinical development stages.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key building block in the synthesis of enantiomerically pure Salmeterol and its derivative APIs for inhalation products.
• Respiratory Drug R&D: Used in preclinical and clinical research for developing new long-acting β-agonists (LABAs) for asthma and chronic obstructive pulmonary disease (COPD).
• Chiral Synthesis: Serves as a high-value chiral starting material or reference standard for asymmetric synthesis in pharmaceutical manufacturing.
• Analytical Reference Standard: Provides a certified standard for quality control, method development, and regulatory compliance testing in pharmaceutical analysis.
• Formulation Development: Employed in the development of stable and efficacious dry powder inhaler (DPI) and metered-dose inhaler (MDI) formulations.

Basic Information

Product Name	(R)-Salmeterol 1-Hydroxy-2-Naphthoic Acid Salt
CAS No.	135271-49-7
Molecular Formula	C25H33NO4 • C11H8O3
Molecular Weight	603.69 g/mol (for the salt)
Synonyms	(R)-Salmeterol Xinafoate; Salmeterol 1-Hydroxy-2-naphthoate (R-enantiomer); (R)-Salmeterol Hydroxynaphthoate; 4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol 1-Hydroxy-2-naphthoate (R)-; (R)-2-(Hydroxymethyl)-4-[1-hydroxy-2-[[6-(4-phenylbutoxy)hexyl]amino]ethyl]phenol 1-Hydroxy-2-naphthoate; GSK 961081 (R-enantiomer salt); Long-acting β-2 adrenoceptor agonist salt.
EINECS	Contact for details

Quality Control

Our (R)-Salmeterol 1-Hydroxy-2-Naphthoic Acid Salt is manufactured under strict quality systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling to ensure it meets the exacting standards for pharmaceutical intermediates. We provide full traceability and Certificates of Analysis (COA) detailing all test results. Our quality commitment aligns with ICH guidelines and supports regulatory filings for drug development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccated environments.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.5%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤1.0%
Any single unknown impurity	≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.2%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.