Description

(S)-Salmeterol CAS NO 135271-48-6 is the pharmacologically active enantiomer of the long-acting beta2-adrenergic receptor agonist (LABA) salmeterol. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure pharmaceutical formulations, ensuring targeted therapeutic efficacy and minimizing potential side effects. It is an essential building block for advanced pharmaceutical companies and research institutions focused on respiratory therapies, chiral synthesis, and analytical method development.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Primary use in the synthesis of enantiopure salmeterol xinafoate for asthma and chronic obstructive pulmonary disease (COPD) medications.
• Chiral Reference Standard: Serves as a critical standard for HPLC, GC, and other analytical methods to ensure enantiomeric purity in quality control laboratories.
• Pharmaceutical R&D: Used in preclinical and clinical research to study the specific pharmacokinetics and pharmacodynamics of the (S)-enantiomer.
• Asymmetric Synthesis: A valuable chiral precursor or template for developing novel β-agonist compounds and other therapeutic agents.
• Regulatory Submissions: Provides the necessary certified material for drug master file (DMF) submissions and regulatory compliance documentation.

Basic Information

Product Name	(S)-Salmeterol
CAS No.	135271-48-6
Molecular Formula	C25H37NO4
Molecular Weight	415.57 g/mol
Synonyms	(S)-Salmeterol; Salmeterol Impurity C (EP); (S)-4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol; (R,R)-Formoterol related compound; 1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-2-[[6-[4-(phenylbutoxy)hexyl]amino]-1-hydroxyethyl] alcohol (S-enantiomer); Long-acting beta2-adrenergic agonist intermediate; Serevent impurity
EINECS	Contact for details

Quality Control

Our (S)-Salmeterol is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards suitable for pharmaceutical R&D and intermediate synthesis. Comprehensive analytical testing includes chiral purity assay, identification, and impurity profiling via HPLC and other pharmacopeial methods. Certificates of Analysis (COA) are provided with each shipment, detailing all specification results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere (e.g., nitrogen) in the original packaging to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.