Description

R-(-)-Salmeterol is the pharmacologically active enantiomer of the long-acting beta2-adrenergic receptor agonist (LABA) salmeterol. This high-purity chiral intermediate is critical for ensuring the efficacy and safety profile of advanced respiratory therapeutics. It is primarily required by pharmaceutical R&D and manufacturing sectors for the development and production of enantiomerically pure asthma and chronic obstructive pulmonary disease (COPD) medications.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the manufacture of enantiopure salmeterol xinafoate.
• Pharmaceutical Reference Standard: Used in analytical laboratories for method development, validation, and quality control testing of drug substances and products.
• Respiratory Drug R&D: Essential for research into new long-acting bronchodilators and combination therapies for asthma and COPD.
• Metabolite Studies: Employed in pharmacokinetic and metabolic pathway research to understand drug action and clearance.
• Chiral Catalyst/Resolution Studies: Serves as a model compound in developing asymmetric synthesis or chiral separation techniques.

Basic Information

Product Name	R-(-)-Salmeterol
CAS No.	135271-47-5
Molecular Formula	C25H37NO4
Molecular Weight	415.57 g/mol
Synonyms	(R)-Salmeterol; (R)-(-)-Salmeterol; Salmeterol R-(-)-enantiomer; (R)-4-Hydroxy-α1-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-1,3-benzenedimethanol; 1-[4-Hydroxy-3-(hydroxymethyl)phenyl]-2-[[6-[4-(phenylbutoxy)hexyl]amino]ethyl]amino]ethanol (R-enantiomer); GSK-961081 (enantiomer); GW-642444 (enantiomer)
EINECS	Contact for details

Quality Control

Our R-(-)-Salmeterol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity, and enantiomeric excess is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.