Description

4-(Chloromethyl)-2-(Trifluoromethyl)Thiazole is a high-value, multi-functional heterocyclic building block. This compound is critical for the synthesis of advanced molecules, particularly in the pharmaceutical and agrochemical sectors, due to its reactive chloromethyl and electron-deficient trifluoromethylthiazole moieties. It is primarily sought by R&D chemists and process development teams for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel drug candidates, especially in antiviral, antibacterial, and central nervous system (CNS) therapeutic areas.
• Agrochemical Active Ingredient Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides, leveraging the biological activity of the thiazole core.
• Material Science Precursor: Serves as a building block for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of chemical probes and affinity tags for studying biological systems.
• Cross-Coupling Reactions: The chloromethyl group allows for further functionalization via palladium-catalyzed or nucleophilic substitution reactions.
• Fluorinated Compound Library Synthesis: Essential for creating diverse compound libraries in medicinal chemistry, benefiting from the properties imparted by the trifluoromethyl group.

Basic Information

Product Name	4-(Chloromethyl)-2-(Trifluoromethyl)Thiazole
CAS No.	135207-07-7
Molecular Formula	C5H3ClF3NS
Molecular Weight	201.60 g/mol
Synonyms	2-(Trifluoromethyl)-4-(chloromethyl)thiazole; 4-Chloromethyl-2-trifluoromethylthiazole; 2-Trifluoromethyl-4-chloromethylthiazole; Thiazole, 4-(chloromethyl)-2-(trifluoromethyl)-; 4-(Chloromethyl)-2-(trifluoromethyl)-1,3-thiazole
EINECS	Contact for details

Quality Control

We maintain stringent quality control protocols for all our fine chemical intermediates. Production of 4-(Chloromethyl)-2-(Trifluoromethyl)Thiazole adheres to current Good Manufacturing Practices (cGMP) where applicable. Every batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Recommended storage temperature is 2-8°C for long-term stability. Keep away from heat and incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.